The MitoBrainMap: a cube-sized map of brain deficits in people with mitochondrial disease. Neurobiology and psychobiology
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The map, which the study’s authors call the MitoBrainMap, is “both technically impressive and conceptually groundbreaking”, says Valentin Riedl, a neurobiologist at the Technical University of Munich in Germany, who was not involved in the project.
The brain’s mitochondria are not just bit-part players. Martin Picard is a psychobiologist at Columbia University in New York City, and a co-author of the study. And the brain accounts for 20% of the human body’s energy usage2.
Wielding a tool typically used for woodworking, the study’s authors divided a slice of frozen human brain ― from by a 54-year-old donor who died of a heart attack ― into 703 tiny cubes. The cube sizes are equivalent to the size of units that make up standard 3D images of the brain. “The most challenging part was having so many samples,” says Picard.
Towards a more humane understanding of the human brain and its application to MRI studies of mitochondrial encephalomyopathy with lactic acidosis
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Source: A human brain map of mitochondrial respiratory capacity and diversity
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MitoCarta 3.0 has sub-organelle annotations and is an updated proteome. Nucleic Acids Res. 49, D1541–D1547 (2021).
Source: A human brain map of mitochondrial respiratory capacity and diversity
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Source: A human brain map of mitochondrial respiratory capacity and diversity
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Source: A human brain map of mitochondrial respiratory capacity and diversity
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